Reliable sports bets tricks

Top sports betting recommendations today? The Unpopular Draw: A draw isn’t exactly the most favorable wager, as most people are fascinated by a team’s victory, let alone the fans of a specific team, who will probably not play against it. However, draws are well compensated! It’s sometimes better to aim for a tie rather than a victory or defeat. Let’s not forget that every game begins with a tie and sometimes it also ends that way, as well. So, a good tip here is to look for matches in which both sides have a difficult time beating each other. A good example is one of the top teams in the league playing against an antagonistic top team in its home base. It’s often so difficult for either to win, that they are both content with a tie, which is frequently the outcome. Read extra info at https://okokim.com/.

Betting spreads and totals isn’t enough for most people anymore. Props — short for proposition bets — can be any wager that’s not a standard point spread, moneyline or total. Like point spreads, you often have to pay the corresponding price with props. Here, Scherzer’s strikeout total against the Reds is set at 7.5. But it’s more likely than not he goes under, according to FanDuel’s lines, so you have to pay a steeper price to bet the under than the over. If you’re getting serious about making money betting sports, props are a great place to start. U.S. sportsbooks offer hundreds of props on every game, creating a greater attack surface since they can’t properly price all of them. Even if you’re not creating your own statistical models, tracking specific props and understanding how they’re priced can help give you an edge over the sportsbooks.

How Does Live Betting Work? At its core, live betting is wagering on contests that are actively going on. Before the game starts, there’ll be lines for the moneyline, spread, totals, and more. In live betting, it’s the same thing, but these odds can vary wildly based on where the game is and can switch instantaneously. This bet type allows you to bet on contests you may have forgotten about before the game and provides a unique opportunity at some value, especially if you bet live underdogs that make a comeback. When engaging in live betting, it’s almost always suggested to be watching the game to see what’s happening because context is important.

More sports fans than ever are giving online sports betting a try now that it is legal in 30 states and counting. If online sportsbooks are newly legal in your state, you are probably excited to place your first wager. But if you haven’t placed an online sports bet before, learning the difference between a spread bet and a money line bet can seem a little daunting. All it takes is knowing the most popular sports betting terms to place your first wager like a pro. To help prepare you for a fun sports betting experience, we’ve put together a helpful sports betting guide to get you started. Check out the popular sports betting terminology to see which betting style is right for you.

Can you make money by becoming a Sports Bettor? Yes. Most successful sports bettors make a solid living off their betting game. The idea is to start and gradually build solid skills and knowledge to make the most of every wager placed on sports. What is an acceptable budget to start with Sports Betting? Most sportsbooks will allow sports bettors to start betting with small budgets. Certain bets might have a limit, yet these can range anywhere from $5 to $20. Can I bet on my favorite teams and players? Yes. The piece of advice is to bet on the best available option regardless of one’s preferences as to which teams or players stand as their favorite.

Low-risk methods are the way to go if you are new to betting or intend to play for large bets. Risk-free betting offers are also a vital consideration to consider when deciding which sportsbook to open an account with. Risk-free betting might potentially double the number of bets you can place with your first bet. This betting strategy is essentially the first-time sportsbook bonus offered for new gamblers. If you win a bet, bravo! You won! But if you lose a bet, your money will be returned to you in the form of site credit, a free bet, or bonus cash to use at the sportsbook. Matchup betting, which falls under the risk-free bets category, is a method of betting that employs a mathematical equation to allow clients to profit from bookies’ free bet offers.

Best shopper flow retail services

Footfall counting premium services? People’s shopping habits are evolving slowly. The overall experience is why consumers go to malls despite the internet shopping has grown in popularity. Giving customers a unique experience is becoming more and more prevalent in malls now and in the future. A shopping mall is a social gathering place where individuals may catch up with old friends, make new acquaintances, and engage with various products and brands. With the use of technology, shopping malls are increasingly using consumer profiling to help shops reach their goals. Mall managers will need to grasp two sets of technology to provide a seamless client experience.

Link Retail has everything needed in order to get the best performance out of a retail store or mall. Every individual part, from the shelving, promotions, communication between employees, traffic, conversion rates, customer behavior, and more, can be properly cataloged by a version of our cutting edge Link Retail software. This will give store owners the vital information they need in order to design a better and more profitable shop. This will give a large advantage over others who do not use this technology. The hyper-competitive nature of the retail space requires store runners to try to find a leg up wherever possible. Link Retail can give you that leg up. There is nothing that we like more than seeing a struggling store turn it around or a successful store soar to new heights. Read even more details at retail waste management.

The stores are our laboratory –and our playground. This is where we find the best solutions -and even if our biggest business today is based on software, we are still very much based our in-store solutions, practical test environments and physical changes in store as a basis for development. The Retail Lab as a concept is a new way of looking at this, where suppliers are allowed to test out “any idea” at a retailers pilot store. We are happy to tell you much more about this. More details under.

One does not need to have a background in software in order to understand what Link Retail Tools is telling them. So, monitoring while outside the office or store is now much easier than before. POS analytics: Time in-store can be spent without having to disconnect from day-to-day operational numbers. Therefore, you’ll stay in control! Link Retail’s Top 4 Technological Superiorities: Act Rapidly Allow the system to monitor your sales activity and track the number of products displayed in your store.

We are working with leading retailers and brand owners in the retail industry. We are operating in more than 25 countries within all kinds of optimization projects and processes. We provide retail footfall counting, shopper flow analysis, sales insights, shelf optimizations, wastage management and more, a few terabytes of video and POS data is being processed by our AI based analytics per second. Save 5000 bread yearly for just one store! Discover additional details at https://linkretail.com/.

Eye Tracking is a unique method for objectively measuring consumer attention and behavior in-store. This is done by using advanced high-tech glasses with a two-way camera, which is further used to show the shopper using the glasses in a “first-person perspective”. The Eye Tracker will register when the shopper’s pupil focuses on a specific object (i.e. a product or a poster) and will re-define this into data points which can then be aggregated for visualization and analysis of the data for several as many consumers as you wish to measure. By using Eye Tracking as a tool for consumer analysis, you will finally get objective answers to your questions, and remove “good intensions” and “subjective opinions” from the equation. Which products are most frequently noticed by the shoppers? How does the shopper navigate in the category/shelf? What share of the in-store communication gets actually seen by the shopper? Which products function as the “anchor” in the shelf and stands out from the rest? This, among several others, are questions you’ll get the answer to from an Eye Tracking study.

Jon Purvis New Orleans

Quality Louisiana, United States restaurant management tricks and tips with Jon Purvis

Excellent New Orleans restaurant management tips and tricks from Jon Purvis? We know what you’re thinking: Manual inventory is traditionally time-consuming. Luckily, advances in tech mean there are inventory management solutions that automate the process, which saves serious time and increases margins to boot. If you’re in a state that permits hosting happy hours, this can be a prime opportunity for your restaurant to bring in additional sales. Happy hours, which typically fall on weekdays between 4-7 p.m., are ideal for people who are getting off of work and looking to meet up with coworkers or friends for a quick drink before heading home. Come up with a few easy-to-make drinks and appetizers that are discounted to entice customers, like half-off nachos or $5 margaritas. You can even go as far as to create full happy hour menus.

Jon Purvis New Orleans

But before we jump into those tips, we want to make sure you know exactly why these tips are worth your time. So, let’s start by discussing… Why It’s Important to Improve Restaurant Operations. You may be spending valuable time and money on things that don’t actually help your restaurant. But this isn’t really your fault. Since the start of the pandemic, it has become difficult to know what’s worth investing in and what’s not. Unfortunately, if you take a haphazard approach to figure this all out, you might find yourself in a lot of trouble. The National Restaurant Association reports that, in 2020, more than 110,000 eating and drinking businesses shut down for good by December 1 as a result of the Covid-19 pandemic. On top of that, the restaurant industry as a whole lost around $240 million in sales!

Jon Purvis restaurant success guides : Listen to the customer The first step is to listen to the complaint carefully and understand the issue from the customer’s perspective. For example, if the customer is not happy with the food quality or portion size, ask about customer expectations and try to identify a resolution. Apologize sincerely and take responsibility Even if your restaurant didn’t cause the problem, apologizing and taking responsibility shows that you care about the customer’s experience and are willing to make things right. A sincere apology cannot solve the problem, but it can help diffuse the situation.

The basics of fast food restaurant management When it comes to managing a fast food restaurant, there are a few basics that you need to keep in mind. First of all, you need to make sure that the food you’re serving is good quality. This means using fresh ingredients and cooking the food properly. You also need to ensure that your restaurant is clean and presentable. This includes everything from the dining area to the kitchen. Customers will not want to eat in a dirty or messy restaurant.

Jon Purvis Louisiana

If you’re new to restaurant management, figuring out where to begin can be daunting. Your tasks often include handling community outreach, mediating staff conflicts, crunching inventory numbers, meeting customer expectations, and more, all while making sure both the front and back of house run smoothly. From prioritizing to delegating, restaurant managers need to tap into a variety of skills to be successful. Luckily, we’re here to help! We’ve got a few restaurant management tips that will help you feel confident tackling the next steps of your career in this fast-paced industry.

Best bathroom mirrors wholesale manufacturer

Mirrors manufacturer 2022? The metal frame of the metal frame mirror can effectively protect the mirror around it from being damaged, and it can be shaped into various shapes to meet the needs of various collocations. The exquisite and chic metal frame contrasts with the mirror glass to create an impressive focal point for any bathroom. The space brings a sleek Art Deco feel, adding a discreet, contemporary quality. The materials are stainless steel, iron, aluminum alloy, etc., and the colors are mainly gold, silver, white, black, etc., mirror custom、custom framed mirrors design. Find additional information at wholesale mirror suppliers.

Thin steel frames are a popular choice as they go with most design choices. You can have them in black, which is the most popular option, or in white and even in their raw color. If you prefer something warmer, gold is also a great option. Having a thin frame helps open up your mirror more, which in turn, helps open up your space. Thick frames are still in but work best if you have a smaller vanity. If you like the look of both, you can always just mix them. A wood frame with some metal accents is always fun and gives a cool rustic industrial look. A metal frame with a built-in wooden shelf is a cool and functional modern farmhouse option. When it comes to interior design, sometimes going against suggestions, is a beautiful thing.

It’s no secret that mirrors in the interior do not have to be used alone. On the contrary, you can make voluminous and incredibly stylish compositions from mirror elements that can become a real decoration of your interior. Today you can show your imagination and boldly combine accessories of various shapes or sizes – but if you are not sure of your own taste, then you can easily use existing ready-made solutions: mirrored 3D panels – one of the sensational innovations for an original result; compositions of rhomboid beveled mirrors; combinations of small mirrors of various shapes – round, hexagonal, abstract; a variety of several identical mirrors on one wall – in a line or in the form of an intricate collage.

A wall mirror design can be an important asset when decorating. Because it reflects light, it helps to brighten and expand even the smallest and darkest rooms, making them more comfortable and inviting. A decorative wall mirror can also add a decorative touch to your room and it is the ideal focal point of your space. No matter where you place it in your home, it creates a refined, spacious aesthetic. Types of hanging mirrors are: home decor mirrors, hotel mirrors, living room mirrors, bedroom mirrors, custom mirrors Reflect and open your space with our stunning collection of Wall Mirrors. Find additional info at https://www.jhdglass.com/.

Breath of Venice: When discussing décor trends for 2022, it would be wrong not to mention the legendary Venetian mirrors. Accessories with elaborate, voluminous frames have been popular for centuries and are still used as luxurious, expressive accents. Today, such products look very organic not only in art deco bedrooms and classic living rooms – but also in rooms decorated in the most modern, even laconic styles. Today experts recommend taking a closer look at the following options: flattened exquisite silver-colored frames; strict geometric shapes – primarily a rectangle and an octagon; frames with floral motives; crisp geometric patterns – including the Greek meander.

Lavender Essential Oil online store in India

Quality Pumpkin Seeds online shopping? Vihado is one stop online destination for all the health and beauty products, as well as diet and nutrition consultation for being supremely fit and healthy. We are a young team of nutritionists and selling finest nutritional supplements and health products at competitive prices online in a hassle-free and effortless way. We also provide diet and nutritional guidance to reach your health and fitness goals in an effective way. We are confident that you’ll find Vihado to be your first choice for quality, price, reliability and convenience! See additional details on Chia Seeds.

As a natural remedy for body odor, use Tea Tree oil as a natural deodorant by applying 2 drops directly to your underarms after showering to stave off body odor. Be sure to wait about 10 minutes after getting out of the shower, especially if you just shaved, so that your pores can close before applying the oil. Young Living’s Rose Ointment combines moisturizing oils with the soothing qualities of Tea Tree oil, for skin that feels soft and nourished. Hello, gorgeous! Tea Tree oil reduces the appearance of blemishes and helps maintain healthy-looking skin. Just apply 1-2 drops to a cotton ball and rub directly on your face or add a few drops to your favorite Young Living moisturizer or face cream.

Many essential oils have anti-inflammatory, antiviral, antibacterial, antiseptic and anti-fungal properties that help to boost your immune system and fight infections. The chemical substances found in the oils, such as terpenes, esters, phenolics, ethers and ketones, have the potential to fight foreign pathogens that can threaten your health. Some of the best essential oils for your immunity include oregano, myrrh, ginger, lemon, eucalyptus, frankincense, peppermint (or Mentha piperita) and cinnamon. Studies have shown that essential oils effectively destroy several fungal, viral and bacterial pathogens, including methicillin-resistant Staphylococcus aureus, Helicobacter pylori and Candida albicans infections. Because antibiotic resistance is becoming such a major threat in modern health care, using these oils as a form of independent or combination therapy can help to fight bacterial infections in a safer and more natural way.

You may recognize turmeric from your favorite Indian dish. But did you know that research suggests that curcumin (a key component of turmeric) possesses a wide range of beneficial health properties. A 2010 study that found that curcumin has anti-cancer, anti-viral, anti-arthritic and anti-inflammatory properties. Its very strong anti-inflammatory properties are seen as one of the primary drivers of these benefits. You can add turmeric to your foods if you enjoy that flavor or find a curcumin supplement that delivers around 500 miligrams daily.

Drink More Water! Many people mistake the feeling of thirst for the feeling of hunger. Sip on water all day long, making sure to consume 2.5 litres every day. Add in the Fibre. Fibre makes you feel fuller for a longer period of time. However, if you currently don’t eat a lot of fibre, add it in slowly as too much at once can cause digestion issues. Ditch The Soda: There’s nothing worse than drinking empty calories. And choosing diet sodas are no better. Research is showing that diet sodas may actually lead to weight and fat gain. If you need something fizzy to drink, choose sparkling water or make your own water kefir.

Do you know that the grapes are enriched with alpha hydroxy acids which gently exfoliates the skin, reduces fine line from the face to reveal a smoother and younger looking skin. Yes, they are that miraculous! Rub some grapes juice on the face and wash for after 20 minutes. It helps in getting a wrinkle free skin for a longer time. Therefore, this makes grapes extremely good natural product to include in your anti aging skin care regimen. Lemons have been used in beauty rituals since ages due to their excellent capabilities to fade spots, make skin fairer and high Vitamin C content. Dark spots and patchy skin is also associated with skin aging. Lemon juice has vitamin C and skin lightening properties, therefore to even tone the patchy skin and to lighten the age spots. Dab some lemon juice over the patchy areas and dark spots daily before going to bed. Soon they will be treated.

Calcium. All the vitamin D in the world won’t protect your bones unless you get enough calcium. In theory, diet can fill the bill, but many of us don’t consume enough dairy products and other calcium-rich foods. The Recommended Dietary Allowance (RDA) of calcium for men is 1,000 milligrams (mg) before age 71 and 1,200 mg thereafter. If your diet falls short, supplements make sense; calcium carbonate and calcium citrate are best. Although many doctors routinely recommend calcium supplements for women, who have a high risk of osteoporosis, men should limit themselves to the RDA since some evidence suggests very high levels may increase the risk of prostate cancer. And a 2011 report linked calcium supplements, with or without vitamin D, to an increased risk of heart disease. It’s not a proven risk, but it underlines the need for careful study of the risks and benefits of supplements, including the popular items that “everybody knows are good for you.”

Parsley leaf (Petroselinum sativum): Parsley is a highly nutritious member of the umbelliferous vegetable family. It has many health benefits and has been used for 100’s of years as a natural remedy for many conditions and as a food. It contains a host of nutrients such as Vitamin A, C, E, bioflavonoids, iron, folic acid, volatile oils, coumarins, flavonoids and chlorophyll. Parsley contains more vitamin C than any other culinary vegetables i.e. approximately three times as much as found in oranges and about the same amount as black currants. It’s iron content is also high (around twice as much as spinach). The plant is a good source of manganese, calcium and potassium. Also acts as an antioxidant. Parsley is one of the most important culinary herbs for providing vitamins – it is an immune system multi-vitamin and mineral complex all by itself.

Chia seeds come in both black and off-white, but there is little flavor difference and no proven major nutritional advantages of choosing one over the other. Unlike flax, chia does not need to be ground for its nutrients to be properly absorbed in your body. Eating more chia can be as simple as sprinkling it over your oatmeal, yogurt, cottage cheese, steamed or roasted vegetables, and fruit salads. Vihado points out that you can also blend them into your smoothies for a nutritional boost and incorporate them into homemade energy bars and balls. The high amount of soluble fiber in chia forms a gel when mixed with water—a quirk that you can take advantage of to create better-for-you puddings and jams. For instance, for a nutritious chocolate pudding blend together 1/2 cup milk, 1/2 cup plain yogurt, 1 tablespoon cocoa powder, 1 teaspoon honey, 1 teaspoon vanilla extract and 1/2 teaspoon cinnamon. Pour into a jar and stir in 3 tablespoons chia seed. Seal shut and chill until thickened, about 2 hours. Or make a thirst-quenching, hydrating chia fresca by stirring together 1 cup water, 2 teaspoons chia seeds, juice of 1/2 lemon or lime and 2 teaspoons honey or agave syrup. Let sit for a few moments to thicken slightly. Find additional information on https://vihado.in/.

Complete lottery services advices right now

High quality online casino provider reviews today? Promotions! Surely when you participate in betting, you are also very interested in the promotions of the house. Understanding the wishes of customers, at MOTO88, we always offer a lot of incentives for participating members. As soon as you create an account successfully, you will immediately receive a bonus for newcomers. The number of promotions is diverse and constantly updated, but the quality of the promotions that members receive is not low, on the contrary, these are all programs with top payback rates compared to current bookies. now. Read even more details at https://moto88.win/.

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Spending too much on betting can lead to all kinds of problems. No-one has an infinite amount of money, so everyone has to manage their finances to some extent. There are certain living costs that should always be the priority. Gambling with disposable income is fine, but gambling with money that is needed for other things is not. That’s when gambling can start to get out of control, and the consequences can be dire. This is easily avoided by simply sticking to a budget. Sports betting is far more likely to be an enjoyable experience when it’s affordable, and there’s no need to worry about whether a wager wins or loses. Ideally, you should also use a staking plan. A staking plan is basically just a set of rules that determine how much should be staked on each wager relative to the size of your budget. We recommend staking around 1-2%, and definitely no more than 5%. This will allow you to withstand a few losses without blowing your whole budget too quickly.

Although deposit bonuses might theoretically also be given to existing players (see ‘reload bonuses’ below), this term is generally used to refer to bonuses given to new players for making their first deposit or a certain number of deposits (e.g. for their first 3 deposits). That’s why these bonuses are also called welcome bonuses or sign up bonuses. The value of deposit bonuses is usually linked to the amount of the player’s deposit, usually expressed as a certain percentage of the deposited money. This means that the more you deposit the more you get, but there is almost always a specific limit that restricts the total value of the bonus.

Online gambling winning guides… everyone wants to win at casino! Swing the Odds in Your Favour : Knowing the odds of a game is essential but delving a bit deeper gives you an extra edge. Spend some time learning the strategies and get to grips with the probabilities of your chosen game. You’ll soon be rewarded by a growing account balance.

Only a small percentage of sports bettors are profitable in the long run. The reality of sports betting is that the majority of people lose money at it. There are several reasons for this, but they’re not important right now. What IS important is that you understand that you’re more likely to lose than win as a beginner. Some people start betting on sports with the belief that they can rely on their sports knowledge to beat the bookmakers. This is a mistake! It’s definitely possible to make a profit from sports betting, but it takes more than a little sports knowledge. Even a truly extensive knowledge is not enough by itself. There’s a lot that’s required to be a successful sports bettor, so please don’t think that you’re going be winning from the moment you start.

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Không ai có số tiền là vô hạn, vì vậy ai cũng phải quản lý tài chính của mình ở một mức độ nào đó. Có một số chi phí sinh hoạt nhất định luôn phải được ưu tiên. Đánh bạc với thu nhập khả dụng là được, nhưng đánh bạc với số tiền cần thiết cho những việc khác thì không. Đó là khi cờ bạc có thể bắt đầu mất kiểm soát và hậu quả có thể rất thảm khốc. Điều này có thể dễ dàng tránh được bằng cách chỉ cần bám vào ngân sách. Cá cược thể thao có nhiều khả năng là một trải nghiệm thú vị khi giá cả phải chăng và không cần phải lo lắng về việc đặt cược thắng hay thua. Tốt nhất, bạn cũng nên sử dụng một kế hoạch đặt cược. Kế hoạch đặt cược về cơ bản chỉ là một tập hợp các quy tắc xác định số tiền nên đặt cho mỗi lần đặt cược liên quan đến quy mô ngân sách của bạn. Chúng tôi khuyên bạn nên đặt cược khoảng 1-2% và chắc chắn không quá 5%. Điều này sẽ cho phép bạn chịu được một vài khoản lỗ mà không phải thổi toàn bộ ngân sách của bạn quá nhanh.

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Sustained IGF-1 delivery research from Karim Sarhane today

Peripheral nerve regeneration research by Karim Sarhane right now? One-fifth to one-third of patients with traumatic injuries to their arms and legs experience nerve injury, which can be devastating. It can result in muscle weakness or numbness, prevent walking or using the arms, and reduce the ability to perform daily activities. Even with surgery, some nerve injuries never recover, and currently there are not many medical options to address this problem. In 2022, the researchers plan to perform this research on more primates to triple the size of the original group. The study can then move into phase I clinical trials for humans.

Dr. Sarhane is published in top-ranked bioengineering, neuroscience, and surgery journals. He holds a patent for a novel Nanofiber Nerve Wrap that he developed with his colleagues at the Johns Hopkins Institute for NanoBioTechnology and the Johns Hopkins Department of Neuroscience (US Patent # 10500305, December 2019). He is the recipient of many research grants and research awards, including the Best Basic Science Paper at the Johns Hopkins Residents Research Symposium, the Basic Science Research Grant Prize from the American Foundation for Surgery of the Hand, the Research Pilot Grant Prize from the Plastic Surgery Foundation, and a Scholarship Award from the American College of Surgeons. He has authored to date 46 peer-reviewed articles, 11 book chapters, 45 peer-reviewed abstracts, and has 28 national presentations. He is an elected member of the Plastic Surgery Research Council, the American Society for Reconstructive Microsurgery, the American Society for Reconstructive Transplantation, and the American Society for Peripheral Nerves.

The hydrogels were soaked in IGF-1 solutions, with concentrations ranging from 0.05 to 1 mg/ml. The duration of soaking time and biomaterials used for fabrication differed between studies, thereby complicating further direct comparisons beyond individual consideration. Regardless of concentration of IGF-1 soaking solution, duration of soaking time, or hydrogel composition, the fundamental property in predicting utility for nerve regeneration is the sustained concentration of released IGF-1 that is reaching the site of PNI. Unfortunately, only two of the studies included in Table 6 quantified IGF-1 release in vivo using either fluid sampling with ELISA or radiolabeled IGF-1 (Yuan et al., 2000; Kikkawa et al., 2014). Using ELISA, one study reported significantly greater in vivo IGF-1 concentration, peaking at 1.25 µg/mL at Post-operative Day 1 (POD 1) and returning to the physiologic levels of the control group by POD 7 (Kikkawa et al., 2014). Using radiolabeling, the other in vivo quantification study reported a biphasic IGF-1 release profile with an initial burst of approximately 80% of the starting concentration of IGF-1 at 1 h followed by sustained release of the remaining 15% ± 2.9% over the subsequent 48-h period (Yuan et al., 2000). Conversely, a different study reported failure of IGF-1 to prevent motoneuron death, a finding which was noted to be contrary to previous results and required additional investigation. This study described the use of a soaked gel foam plug but did not specify the IGF-1 release profile of this material (Bayrak et al., 2017). As such, further analysis and testing is needed to determine the optimal fabrication parameters, loading strategy, and concentration of released IGF-1 required for successful local delivery via hydrogel.

Recovery by sustained IGF-1 delivery (Karim Sarhane research) : Under optimized conditions, uniform PEG-b-PCL NPs were generated with an encapsulation efficiency of 88.4%, loading level of 14.2%, and a near-zero-order release of bioactive IGF-1 for more than 20 days in vitro. The effects of locally delivered IGF-1 NPs on denervated muscle and SCs were assessed in a rat median nerve transection-without- repair model. The effects of IGF-1 NPs on axonal regeneration, muscle atrophy, reinnervation, and recovery of motor function were assessed in a model in which chronic denervation is induced prior to nerve repair. IGF-1 NP treatment resulted in significantly greater recovery of forepaw grip strength, decreased denervation-induced muscle atrophy, decreased SC senescence, and improved neuromuscular reinnervation.

Peripheral nerve injuries (PNIs) affect approximately 67 800 people annually in the United States alone (Wujek and Lasek, 1983; Noble et al., 1998; Taylor et al., 2008). Despite optimal management, many patients experience lasting motor and sensory deficits, the majority of whom are unable to return to work within 1 year of the injury (Wujek and Lasek, 1983). The lack of clinically available therapeutic options to enhance nerve regeneration and functional recovery remains a major challenge.

The amount of time that elapses between initial nerve injury and end-organ reinnervation has consistently been shown to be the most important predictor of functional recovery following PNI (Scheib and Hoke, 2013), with proximal injuries and delayed repairs resulting in worse outcomes (Carlson et al., 1996; Tuffaha et al., 2016b). This is primarily due to denervation-induced atrophy of muscle and Schwann cells (SCs) (Fu and Gordon, 1995). Following surgical repair, axons often must regenerate over long distances at a relatively slow rate of 1–3 mm/day to reach and reinnervate distal motor endplates. Throughout this process, denervated muscle undergoes irreversible loss of myofibrils and loss of neuromuscular junctions (NMJs), thereby resulting in progressive and permanent muscle atrophy. It is well known that the degree of muscle atrophy increases with the duration of denervation (Ishii et al., 1994). Chronically denervated SCs within the distal nerve are also subject to time-dependent senescence. Following injury, proliferating SCs initially maintain the basal lamina tubes through which regenerating axons travel. SCs also secrete numerous neurotrophic factors that stimulate and guide axonal regeneration. However, as time elapses without axonal interaction, SCs gradually lose the capacity to perform these important functions, and the distal regenerative pathway becomes inhospitable to recovering axons (Ishii et al., 1993; Glazner and Ishii, 1995; Grinsell and Keating, 2014).

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