Peripheral nerve regeneration research and science from Karim Sarhane today

Peripheral nerve regeneration studies with Karim Sarhane today? Insulin-like growth factor 1 (IGF-1) is a hormone produced by the body that has the potential to be used as a treatment for nerve injuries. IGF-1 may help heal nerve injuries by decreasing inflammation and buildup of damaging products. Additionally, it may speed up nerve healing and reduce the effects of muscle weakness from the injury. However, a safe, effective, and practical way is needed to get IGF-1 to the injured nerve.

Dr. Karim Sarhane is an MD MSc graduate from the American University of Beirut. Following graduation, he completed a 1-year internship in the Department of Surgery at AUB. He then joined the Reconstructive Transplantation Program of the Department of Plastic and Reconstructive Surgery at Johns Hopkins University for a 2-year research fellowship. He then completed a residency in the Department of Surgery at the University of Toledo (2021). In July 2021, he started his plastic surgery training at Vanderbilt University Medical Center. He is a Diplomate of the American Board of Surgery (2021).

The combination of nanoparticle carriers with hydrogels as a hybrid delivery system has recently come into favor for purposes including passively controlled drug release, stimuli-responsive drug delivery, site-specific drug delivery, and detoxification. The addition of a hydrogel to a nanoparticle delivery system allows for an added level of tunability as well as increased assurance that the nanoparticles remain at the local site of delivery in vivo (Gao et al., 2016; Norouzi et al., 2016). A promising approach being pursued by our group for repair of PNI involves encapsulation of IGF-1 into nanoparticles that provide sustained release of IGF-1 for over 6 weeks. The nanoparticles are then suspended within a biomimetic nanofiber hydrogel composite carrier to facilitate in vivo application and preliminary results have been encouraging (Santos et al., 2016). The approach involves injection of the composite hydrogel into the denervated target muscle and around the nerve distal to the site of injury, such that the released bioactive IGF-1 diffuses through the target tissues. Our unpublished data suggests that IGF-1 does not act on regenerating axons in gradient-dependent fashion, as uniform delivery along the distal nerve results in a robust treatment effect. However, the question of gradient dependence has not been specifically addressed to our knowledge and warrants further investigation. To achieve maximal treatment effect, IGF-1 will likely need to be delivered for the duration of the regenerative period, which can last many months or even years. It is unlikely that an engineered drug delivery system will be developed that can achieve this duration of release with a single dose. We therefore anticipate that interval ultrasound-guided reinjections will be needed, with the dosing schedule being dependent on the duration of drug release.

Recovery by sustained IGF-1 delivery (Karim Sarhane research) : The translation of NP- mediated delivery of water-soluble bioactive protein therapeutics has, to date, been limited in part by the complexity of the fabrication strategies. FNP is commonly used to encapsulate hydrophobic therapeutics, offering a simple, efficient, and scalable technique that enables precise tuning of particle characteristics [35]. Although the new iFNP process improves water-soluble protein loading, it is difficult to preserve the bioactivity of encapsulated proteins with this method.

Patients who sustain peripheral nerve injuries (PNIs) are often left with debilitating sensory and motor loss. Presently, there is a lack of clinically available therapeutics that can be given as an adjunct to surgical repair to enhance the regenerative process. Insulin-like growth factor-1 (IGF-1) represents a promising therapeutic target to meet this need, given its well-described trophic and anti-apoptotic effects on neurons, Schwann cells (SCs), and myocytes. Here, we review the literature regarding the therapeutic potential of IGF-1 in PNI. We appraised the literature for the various approaches of IGF-1 administration with the aim of identifying which are the most promising in offering a pathway toward clinical application. We also sought to determine the optimal reported dosage ranges for the various delivery approaches that have been investigated.

Research efforts to improve PNI outcomes have primarily focused on isolated processes, including the acceleration of intrinsic axonal outgrowth and maintenance of the distal regenerative environment. In order to maximize functional recovery, a multifaceted therapeutic approach that both limits the damaging effects of denervation atrophy on muscle and SCs and accelerates axonal regeneration is needed. A number of promising potential therapies have been under investigation for PNI. Many such experimental therapies are growth factors including glial cell line-derived neurotrophic factor (GDNF), fibroblast growth factor (FGF), and brain-derived neurotrophic growth factor (Fex Svenningsen and Kanje, 1996; Lee et al., 2007; Gordon, 2009). Tacrolimus (FK506), delivered either systemically or locally, has also shown promise in a number of studies (Konofaos and Terzis, 2013; Davis et al., 2019; Tajdaran et al., 2019).

Bästa betyg förhållande dating guider

Högsta betyg vuxen dating guider? Om du är för skrämd för att närma dig den typ av kvinna du tror att du förtjänar, samtidigt som du avvisar alla de som visar intresse för dig, kommer du att förbli singel under lång tid. Seriedejting händer när en kille inte har slagit sig ner för att verkligen förstå vad han vill ha i en kvinna. Dessa typer av killar närmar sig nästan varje tjej de ser. De använder enbart yttre skönhet som mätvärde för att utvärdera tjejer. De har inga normer eller dygder de vill ha hos en kvinna. Deras fokus är helt enkelt att hoppas på att bli avslappnad. Problemet med denna inställning till dejting är att det ofta slutar med att du blir frustrerad och förvirrad. Det är omoget och det är ett orealistiskt sätt att hitta en partner. Du kommer med största sannolikhet att få fler avslag än du kan hantera. Läs mer info at escort Goteborg.

Arbeta igenom ditt bagage. Alla har några skrapsår och ärr från tidigare upplevelser som kan smyga sig in i deras kärleksliv. Till exempel kanske dina föräldrar misslyckades med att visa dig konsekvent tillgivenhet, och nu känner du att du är extra behövande i relationer. Eller så kanske ditt ex var otrogen mot dig och lämnade dig med några allvarliga förtroendeproblem. Oavsett vilket bagage du bär med dig är det dags att gräva djupt och arbeta igenom det. Annars kan det visa sig vara näst intill omöjligt att ha en sund relation med någon ny. Slutsats? Rensa ditt sinne från “den som kom undan” och du kommer att ha mycket lättare att känna igen någon fantastisk när du ser dem. Oavsett om det innebär att meditera, arbeta med en terapeut eller dejtingcoach, utöva egenvård eller hålla dig sysselsatt med hälsosamma distraktioner, är poängen att du kommer att vara mycket mer sannolikt att faktiskt uppnå dina romantiska mål IRL, snarare än bara i ditt huvud.

Nästa steg: Att spela hårt att få eller vänta på att den andra personen ska göra det första draget. Förutom föråldrade könsroller kommer dessa “regler” från idén att den som bryr sig mindre i förhållandet är den som har mest makt. Men ska kärlek handla om makt? Det är OK att bry sig; vi ska bry oss om varandra. Så vad spelar det för roll om du “kommer för stark” eller “bryr dig mer?” Var sann mot dina känslor och vad du vill. Åh, och att göra det första steget kan spara oss mycket tid på att undra om de gillar oss tillbaka.

En anledning till att många singlar kämpar för att hitta varaktig kärlek är att de har vad som kallas en “dålig väljare”. De fortsätter jaga efter samma typ av person – säg en dålig pojke med rädsla för engagemang, en vacker men ytlig kvinna som bara är ute efter sina pengar, eller en kontrollerande man som de misstar sig för att vara omtänksam och skyddande. Sedan undrar de varför alla deras relationer verkar sluta på samma sätt. Om du har haft deja vu i dejting – och inte på ett bra sätt – är det förmodligen en bra idé att skaka om och komma ur din komfortzon. Närmare bestämt, att låta någon annan hitta dig en dejt kan förhindra dig från att falla offer för samma gamla giftiga vanor.

Kommunikationsförmåga kan skapa eller bryta vilken dejtingsituation som helst. Ett exempel: om det faktum att en dejt inte har introducerat dig för sina vänner stör dig, och du inte säger något till dem om det, kommer du förmodligen att bygga upp förbittring tills du exploderar – och sedan kommer att bli blind. Så återigen, gör det till en punkt att börja dela dina behov, önskemål och känslor med personerna du dejtar. Det kan kännas läskigt i början, men det kommer att löna sig i det långa loppet genom att hjälpa dig att A) bättre utvärdera din kompatibilitet med någon tidigt och B) undvika onödiga konflikter.

Har du ett ex som har hängt med i flera år eller en jävla pojke som har bråkat med ditt huvud? Hur är det med de människor du sms:ar när du känner dig ensam eller uttråkad eller som du tror att du kan vara intresserad av någon gång? Jag kallar dessa människor “kanske:” exen, tidigare dejter och “det är komplicerade” relationer som inte fungerade första gången, men du behåller deras nummer i din telefon “för säkerhets skull” eller hoppas att något kommer förändra.

Överväg en lågmäld kaffe, te, en promenad eller en drink istället för middag: Istället för att träffas för middag på första dejten, välj en aktivitet som är potentiellt kortare och mer avslappnad som en promenad eller en kaffe. På så sätt, om du efter 45 minuter inser att du helt enkelt inte är kompatibel, är du inte bunden till en längre (och potentiellt dyr!) middag som kan vara obehaglig och besvärlig för båda parter. Om dejten går bra kan du fortsätta att drinka eller äta middag och fortsätta konversationen. Även om det är lätt att lägga till ett mellanmål eller en bit, är det svårare att ta sig ur middagen.

MIG welders shopping UK

Plasma cutters online shopping in the UK right now? A cutting disc, also known as a slitting disc, is an abrasive disc that is used to cut through material. Common materials that are cut with a such a disc include steel, stainless steel & aluminium. These discs are a consumable item, therefore they are often sold in multiples. Their expendable nature means the user has to replenish their stock when they are running low. Cutting discs are usually manufactured from fibreglass net, a material that offers abrasive properties and a bonding resin. These components are added together and then formed under a combination of pressure & heat, thus forming a disc that can be used to cut through materials. Read extra information at cutting discs.

Carrying cylinders of gas around with you to jobs as a mechanic or manufacturing welder isn’t always as simple as it seems. Many people are beginning to think that the best MIG welder may be one that can deliver a gas-free performance. The Sealey MightyMIG90 welder is a small MIG welding machine that’s designed to fit in the back of your van with ease. The unit is set up and ready for you to start using the moment that it arrives, and it comes with a comfort grip non-live torch included. Sealey has a reputation for being one of the largest brands for manufacturing tools and equipment in Europe. Not only do you get a welding mask included with your professional-level non-gas welder, but you also get a warranty for twelve months of peace of mind. Many customer reviews about this home welder suggest that Sealey offer exceptional customer service and that the company can deliver replacement parts when needed too. If you’re looking for a convenient and straightforward welder, then the MightyMIG90 might be the best way to go. It’s incredibly easy to use whether you’re a beginner or full-time welding professional.

If you’re looking for quality metal grinding wheels, Makita is a brand worth checking out. This wheel is perfect for quickly grinding through metal, making it an essential tool for any serious metalworker. With its durable construction and precision-cut teeth, the Makita Metal Cutting grinding wheel is sure to become a favorite in your workshop. These angle grinder wheels are designed for use with Makita 5? angle grinders. It has grain grit, a hard bond matrix, and wheel thickness that provide the best balance. This tool will cut more than other wheels because it’s made of carefully selected materials. You can use it to cut through all metal materials, including metal, steel, and inox steel. In addition, this product can even cut through sheet metal, rebar, steel pipe as well as small to medium diameter pieces of solid material. The grain on these cutting grinding wheels is made from a high-performance aluminum oxide which will provide a long life span for the product. Not only does it lasts a long time but also the material is able to soothe many tough materials with little effort. Read additional info at https://www.weldingsuppliesdirect.co.uk/.

Here’s a lot of welder for the money. The Eastwood MIG 135 industrial Welder features infinite adjustment from 25-135 amps, enough range for 24 gauge sheet metal to 1/4-inch steel plate. It has infinitely adjustable controls and a setup chart on the case cover. It’s also spool gun compatible, giving you the option for 1/4-inch aluminum. The Eastwood MIG 135 industrial Welder mounts 4-inch and 8-inch wire spools, but the wire drive is plastic instead of metal. One other issue with the wire drive is that you’ll need to buy a drive roller if you run flux core wire instead of MIG. Eastwood included the gas regulator and hose for MIG capability, however. It’s got an industry-standard Tweco-style MIG gun for easy-to-find consumables. The connection leads could be longer, but the Eastwood MIG 135 industrial Welder is a versatile, easy to use machine for a great price. If you’re building roll cages or doing chassis work, then you’ll want the model up, the Eastwood 175 Amp MIG Welder is a great 240 volt option that includes the spool gun for aluminum capability right out of the box.

In many shops, the operator has to go to a tool room or supply area for a new contact tip, coil of wire or other welding accessory. This takes valuable time away from the welding cell and slows down overall productivity. To improve the operating efficiency and minimize wasted time, companies should stock at least a limited supply of all necessary items near the welding station – this includes shielding gas, flux and wire. Another helpful productivity enhancing tip is to switch to larger spools of wire such as from 25 lb. spools to 44 or 60 lb. spools to even larger packages of 1,000 lb. reels or 1,000 lb. drums. A simple switch like this means less changeover time, which adds up over the weeks, months and years. Shops should also be on the lookout for shielding gas waste. A simple device called a surge turbine can be placed at the end of the gun to provide a digital readout of the gas surge and flow rate. If the surge rate is high, investing in a surge guard can reduce the pressure, eliminating gas surges and waste. Leaks in the gas delivery system can also create a potential loss of money. By looking at the amount of consumables purchased each year and then examining the total gas purchased, a company can determine if there is a significant loss. Welding manufacturers and distributors should be able to provide average utilization figures so that loss can be detected. If there is a loss suspected, one of the easiest ways to check for leaks is to shut off the gas delivery system over the weekend. Check the level on Friday evening and then again on Monday morning to determine if gas was used while the system was in shut down mode.

How to pick a welder tips: Stepped voltage or synergic: Synergic MIG’s have the edge when you’re welding stainless & aluminium as they are pre-programmed, easy to set up & portable. They also provide a better weld characteristic and so give cleaner weld bead with less/no spatter. Inverters: Considerably smaller and lighter and so ideal for site work. All inverters are stepless and so have infinite control. Also cheaper to run power wise. Budget: How much welding are you going to undertake? Gear your purchasing decision around the jobs you will be working on the most. Polarity changeover; A lot of welders at the light industrial end will to be able weld with gasless flux cored MIG wire. Is the switchover easy on the machine you’re considering. Availability of spares & after sales service: Ask where the machine is actually made. Even the more recognised brands largely outsource their production, which can lead to quality and after sales issues with lack of continuity of supply for spares.

The 720 Watt, 6 Amp motor spins the cutting discs up to an impressive 11,000 rpm. That’s more than enough power output to get just about any job done with a 115 mm disc. Weighing in at less than 2 kg, it’s light enough to use one-handed if you’re brave enough. For two-handed use, there’s an indestructible plastic side handle that you can screw into either side. The thing I like about this handle is the 20° angle. You get a better grip for more precise grinding work, compared with standard right-angle grips. Another bonus feature found on this grinder is the soft start. For such a powerful bit of kit, it doesn’t feel like it’s going to jump out of your hand when you turn it on. And thanks to the anti-restart function, it’s safe to use as well.

Some advices about welding equipment, MIG and TIG welders, plasma cutters. MIG welders use a wire welding electrode on a spool that is fed automatically at a constant pre-selected speed. The arc, created by an electrical current between the base metal and the wire, melts the wire and joins it with the base, producing a high-strength weld with great appearance and little need for cleaning. MIG welding is clean, easy and can be used on thin or thicker plate metals. Similar to MIG welding, flux-cored arc welding (FCAW)* is a wire-feed process but differs in that self-shielded flux-cored welding does not require a shielding gas. Instead, flux-cored wire is used to shield the arc from contamination. This is a simple, efficient and effective welding approach, especially when welding outdoors, in windy conditions or on dirty materials. The process is widely used in construction because of its high welding speed and portability.

106 CFM Airflow and 5800 RPM Motor Revolution. BAOSHISHAN fume extractor can generate 106 CFM airflow with 110V power and generates 55 dBA sounds. The motor revolution is at 5800 rpm, which is more than adequate to produce a decent fume extraction system. 3-stage Filter and 99.97% Purification. The device comes with a carbon filter, central HEPA, and cotton filter that ensure 99.97% purification. Harmful gases like hydrocarbons, benzene, hydrogen compounds, formaldehyde, and ammonia are successfully extracted by the BAOSHISHAN fume extractor. The machine can be categorized as the best portable weld fume extractor for DIY soldering, TIG and stick welding, and several other welding jobs.

Welding Supplies Direct are the UK distributor for GPPH welding tables, manufactured to the highest standards in Europe. GPPH’s range of welding benches and tables are laser cut for precision and are used in every branch of industry. These welding tables offer perfect flatness (+/- 0.5MM) & are made from 15MM thick S355J2+N grade steel. Our modular welding benches come equipped with a hole system of all sides (tabletop & all sides); the holes are 28MM in diameter and have a chamfered edge for easy tool assembly. You have the option of standard legs or castors being fitted, too.

If value for money is a priority to you, take a look at this drill from Evolution. It is a solid and durable drill that will get the job done for the professional steelworker as well as the weekend handyman. This drill has a 6-inch stroke length and comes with a 0.5-inch chuck and key. The drilling range has a diameter from 7/16? to 1-1/8? and cutting depth of 2 inches unless you change out the chuck to something else. You can place the feeding handle on either side of the drill, depending on what is comfortable to you. The heavy-duty magnet makes it easy to do overhead or horizontal drilling. An integrated cooling system will keep your magnetic drill press from overheating. There are some drawbacks to this drill. It can only turn at the speed of 570 RPM. This works great for when you are drilling steel or aluminum, but this speed is too high for drilling titanium or stainless steel. This drill may also be more primitive than conventional high-end magnetic drill presses.

Our vision and our distinct set of values drive the success and spirit of our organization. At ESAB, under Colfax leadership, we live our values. As a premiere U.S. welding equipment manufacturer, our vision and values help us to make strategic decisions, allocate resources, and focus our choices every day, domestically and internationally. ESAB offers a world of products and solutions for virtually every welding and cutting process and application. We serve industries that serve the world. The Best Team Wins – Team-oriented, involved associates are our most valuable resource, and we are passionate about attracting, developing, and retaining the best talent. Living this value is done in three primary ways: 1. Building the right team – having the right people to do the job; 2. Creating the right environment – making sure that leaders create an environment where all associates can contribute, and 3. Getting the win – when you have the right people and right environment – it makes getting the win a lot easier!

Miller have spent time crafting a machine to the highest manufacturing standards that is perfect for reducing set up times and welding up to 3/8 in steel. The most notable feature is the Advanced Autoset feature which gets you welding out the box in no time. All you have to do is select your wire diameter, process type and metal thickness and you’re good to go. You can input your parameters manually if you’d prefer, but the Autoset is so advanced that you really won’t need to, the arc quality is spot on. It’s a versatile unit that is dual-voltage and is super lightweight so it’s easy to carry with the handle on the top. There are plenty of other fine details in this machine like the ‘Auto Spool Gun Detect’ which can automatically detect a spool gun and ‘Smooth-Start Technology’ to enable smooth welds. You have to pay a bit more for this welder, but you get a quality machine with fine attention to detail. See the full review here.

The Autojack MIG100 has its flaws but none of them make a convincing enough case to prevent the model’s appearance on our list. It’s a good product for a lot of different reasons. First, it incorporates 4 stage power settings. Add to that the variable wire speed control and you have yourself a truly versatile tool. The internal turbo fan cooling system here is represented by an oversized blower that circulates air at a higher speed. The air vents on the sides of the model are also larger than average, a design solution that improves heat dissipation. Having said that, what we like most about this MIG welder is probably just how suitable it is for people with different levels of expertise, from beginners and hobbyists to experienced welders and professionals.

United Kingdom market choice: The Ironman is a high-powered welder that is very different from the other welders on this list! Boasting more power, the best duty cycle, and a weight that dwarfs the others, the Ironman is nearly without compare. Obviously, this is not the machine that a budding welder should vie for. It’s super heavy duty and will set the consumer back $2000. It welds from 24 gauge to an amazing ½ inch thickness for steel. The Ironman can handle steel, stainless steel, and aluminum. It is capable of Flux core. The “fan-on-demand” cooling system works as needed, offering up a reduced use of power. There are twelve voltage power settings. The Ironman has infinite adjustment for wire speed.

Industrial gas cylinders have been around for a long time. They are widely used for welding, medical applications, fermenting liquids, and several other applications across various industries. In addition to these, new applications for these cylinders are emerging, as new industries and technologies are evolving. These cylinders are filled with low molecular weight chemicals in a gaseous form. Acetylene, oxygen, nitrogen, carbon dioxide, hydrogen, argon, and helium are some gases, which are used regularly. These chemical gases have distinct properties, which are exploited in various industrial applications. If not handled properly, these industrial gas cylinders may be hazardous in various industrial conditions. This post shares some important safety tips for handling industrial gas cylinders in an industrial facility.

Reliable Bernedoodle puppies Phoenix

Best rated Bernedoodle breeders Phoenix, AZ? Here Phoenix Bernedoodles we specialize on funny lovable Bernedoodles. If you are looking to get a Bernedoodle, then please contact us. We are not a big commercial operation, just serious dog lovers who have fallen in love with this special breed. See extra info on Bernedoodle puppies Phoenix. Certain foods that designer dogs, like the Bernedoodle, do not handle very well and are known to cause digestive problems or kill your pet. Since one of the parent breeds, the Poodle, tends toward sensitive stomachs, it is helpful to know what food can wreak havoc on the digestive system of your new family pet. Extreme caution should be taken whenever you feed your dog to ensure that they receive the proper nutrition for an active lifestyle. Just because you like it and can digest it does not mean your pet can!

Never give your Bernedoodle this dog food : Chocolate has a chemical substance called theobromine that is very toxic to dogs. Even though your puppy has gotten into some chocolate behind your back and seemed to handle it all right, the amount of theobromine varies in different applications of chocolate. The toxicity of their consumption of chocolate will depend on three things. Since different amounts of chocolate have different levels of theobromine, owners should use care to avoid chocolate or cocoa. Baking morsels have high levels of theobromine, so no chocolate chip cookies. Even if your puppy does not ingest a toxic level of theobromine, it can cause diarrhea and vomiting.

Pet insurance is one of the tools to show our care for our pets because you are equipped already if something bad may happen to them. You’ll no longer choose between your pet and your money if you’re in a major crisis because you secured them with insurance already. It’s always great to be ready in any circumstances. Those are only some of the pet insurance companies I know that cover shots and vaccinations. If you’re planning to get one, make sure to consider that they are covering shots and vaccinations for your pets.

Why a Bernedoodle Is a Perfect Pet for Your Family? You have just about decided to get a “doodle” dog, but you are unsure whether a Bernedoodle is the best breed. What are some things you should know about Bernedoodles? Any designer dog can be pricey, but you won’t let that stop you from finding the perfect companion for yourself or your family. There are some things you should know before securing one. What size do these dogs come in, and how big can they get? Which is the best for my situation? Are they temperamental? What about separation anxiety? Will you come home to an apartment that is torn to shreds? How are they with other dogs? As you can see, there are lots of questions. Discover extra information on phoenixbernedoodles.com.

Wholesale laptop adapter manufacturer and supplier 2022

Best wholesale laptop adapter manufacturer by laptoprepair.com? If you’re like me, you can’t be without your laptop. From daily work, to taking notes in meetings and even entertainment at home, your laptop goes everywhere with you. All of that productivity and entertainment a laptop offers needs power to keep it going, and a broken or lost laptop charger or power cord will quickly leave you scrambling for a replacement. You may even want to pick up an extra charger so to save you carrying extra cables. So what do you choose? In this article we run through the three main types of laptop power supplies and how you can pick a safe, reliable and affordable replacement. Find additional info at laptop adapter replacement.

I said in the beginning that there were a few caveats. The Voltage needs to be the same or at least very close to that required by the laptop. We would generally not recommend using a charger or more or less than 1V of what is required by the laptop. HP have 18.5V, 19V and 19.5V laptops and we’ve never had a problem with supplying either of these charger for any HP laptop. Fujitsu laptops generally require 20V, but we’ve never had a problem with 19V chargers. You can not however use a 15V charger on a laptop that requires 19V or vice versa. The Polarity must match. Barrel connectors usually have the negative on the outer sheath and the positive inside the inner hole and to be honest we have never come across a laptop charger which is different.

The first thing you’ll want to look at is the adapter’s output voltage. This is extremely important, since a device will only work if it’s receiving the correct voltage. Most laptop chargers are rated for 3, 5, 6, 9, 12, or 18 volts. However, you’ll want to check your owner’s manual or original charger to verify. Voltage corresponds to a circuit’s maximum capacity. If you imagine the circuit as a river, the voltage measures the width of the river bed. Amperage, on the other hand, represents the intensity of power delivery. So a high-voltage, lower amperage charger is like a wide, slow-flowing river. A low-voltage, high-amperage charger is like a narrow whitewater rapids.

If you’re planing to buy an OEM power supply for your laptop, do make sure that its from a reputable company who can provide assurances on their chargers. Universal chargers are commonly available as replacements for many of the leading laptop brands. Some even span multiple brands and are packaged with multiple sets of ‘tips’ or ‘pins’, the part of the charger that connects directly to your laptop. As we covered in our help guide on power supply pin sizes, measuring the pin size required for your laptop can be a real challenge and impossible if you no longer have the original charger to hand. Universal laptop power adaptors are always produced by third party brands, and the same power supply is often re-branded by different companies across popular marketplaces.

This Multiple Laptop Charger comes with a range of tip types making it compatible for use with most laptops. It’s perfect if you’ve lost your charger or own differently branded laptops. It has a slim and lightweight design which makes it ideal for travelling as well as an AC power source so you can plug it into standard wall sockets. We provide the highest quality laptop power adapters with good price and services. We are an experienced manufacturer in doing laptop parts. All laptop adapter chargers are New and passed strict quality assurance procedures such as CE,RoHS,UL,FCC and ISO9001/9002/14001 certifications. Crowberry is your source for new laptop replacement parts?. We have thousands of laptop keyboard models, Lots of AC Adapters and Screens in stock for Types of Laptops and other Devices, Which are Ready To Ship! Find even more information on laptoprepair.com.

Quality and affordable offshore server firm

High quality offshore server hosting provider? Wide range of clients: We have a wide range of clients from across continents who have made Lyrahosting their home for end to end, bespoke hosting solutions. Multilingual: Language should not be hindrance to your hosting needs. We are therefore multilingual in our approach. Be it English, Hindi, Urdu or Italian feel free to get in touch with us and you will get all the support you seek. Discover additional information at 10G Server.

The expression “Offshore” usually implies tax-saving services, different offshore jurisdictions, and the reduction of dependency on in-house solutions. When it comes to hosting services, offshore hosting is a service where your data is hosted on a server outside your country. Any anonymous VPS – Virtual Private Server with overseas datacenters is an offshore hosting solution. Offshore hosting lets you host anonymous content that might be controversial or restricted in your country, thanks to a different offshore jurisdiction. Moreover, offshore hosting solutions hide your digital footprint and your true identity.

Our Reverse Proxy is one of the most effective Layer 7 protection service. Our system is able to detect a DDoS attack in real time and then activate without any delay the necessary protections to ensure that the attack will be mitigated. Our Premium Anti DDoS Protection is the result of the merger between our Reverse proxy that protects Layer 7 attacks and a new IP DDoS Protection technology capable of mitigating the most dangerous Layer 3 and layer 4 attacks. Based on clean traffic, LyraShield Anti DDoS is capable of mitigating up to 1.5Tbps + / 250Mpps

Shared Hosting vs VPS Hosting: A Comparison! You can avoid this problem by using VPS, as the partitioned servers make sure each website works accordingly. However, if you lack the technical knowledge of how to take care of your virtual private server you should consider your options. When poorly managed, it can lead to a whole bunch of other problems. If you are looking for more advanced options for your site, VPS hosting is more suitable than a shared hosting plan. It grants you root access to the server, so you can install your own OS and software to optimize site performance and security. In contrast, using a shared hosting plan limits you only to standardized server setups. This might be more convenient for people who don’t want to meddle with server management tasks on their own.

Of course, the decision of whether or not to go offshore depends on your specific needs and objectives. There are many advantages to using an offshore Web Host over a traditional hosting company. These include the fact that Offshore Hosting is generally cheaper, faster and more secure. Offshore Web Hosts are not bound by your country’s laws or rules either. This means they can provide you with services which may even be illegal in your country, but also makes it easier for them to maintain a higher level of security and privacy compared to traditional Web Hosts which operate out of your country and are therefore bound to the rules and laws that your country follows.

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Websites are by far and away one of the most effective tools that you can use to communicate just about anything, whether it be a brand, a collection of work, or even an online shopping experience. Today websites allow you to let your creativity run wild, and I always want designers to experiment and to push the boundaries of what you can produce. However, regardless of what creative path a designer chooses to follow when it comes to true branding, it’s super important to make a site that stands out. So today, we’re looking at five tips and design principles to keep in mind when designing a new website. Finally, don’t put too much text on any given page. There are far too many examples of websites with big chunks of text throughout, and it just makes for more work for your audience. Thus try to limit the amount of text on the page and use fonts that are going to make life simpler for your audience.

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The ascent of a hybrid blockchain-enabled networks consultant : Mary Ann Holder

The growth of a blockchain multiparty network ecosystems expert : Mary Ann Holder? MaryAnn Holder is Chief Marketing Officer at One Network Enterprises, a provider of the blockchain-enabled network platform, The Real Time Value Network. Back in 2002, Greg Brady, a supply chain visionary and Ranjit Notani a pioneer in multi-enterprise collaboration technology came to the conclusion that the traditional paradigm of business-to-business collaboration built around enterprise-centric software was fundamentally flawed. Businesses must take an outside-in network view and together serve the end consumer. In May 2003, they acquired Elogex, a cloud-based logistics software company, and founded One Network Enterprises with a vision to create consumer-driven business networks. They developed a network platform that enabled entire business communities to collaborate and work together to serve the consumer. Brady and Notani brought the network way of conducting business just as LinkedIn did so to managing professional contacts. They re-imagined how business software is built, delivered, and used for today’s dynamic and highly inter-connected world.

If we need to find ideas on how to engage all these different audience members especially as technology and people evolve, do you look at other industries and see what they’re doing? That’s a good question because we’re evolving so fast. The landscape is changing really quickly. I think people’s consumption is changing very quickly. We look at a lot of different factors. We’re increasingly a social media world and is very heavily influenced by social media, the characters, and the stars and the tenants of that generation that has been raised on a social media platform. It’s multi-generational so we’re we’re consuming things in smaller sound bytes but that doesn’t mean that the smaller sound bytes can’t something very very applicable and really relevant to what your needs are. We look at the social media world. We look at the music world. We look at the fashion world. B2B, oftentimes, we might get stuck in sort of an ivory tower. But, if you look beyond that into the B2C world how consumers are consuming in the consumer market, it really leads in terms of what the next generation of B2B is going to adopt. You can call it a bullwhip effect.

One Network Enterprises, the global provider of multi-party digital network platform and services, today announced that Gartner, Inc., a leading IT research and advisory firm, has positioned the Company as a Leader in its Magic Quadrant for Multienterprise Supply Chain Business Networks report. According to the report, “Multienterprise supply chain business networks support a community of trading partners — of any tier and type within a network — that need to coordinate and execute supply chain processes across multiple enterprises.”

Today, these hybrid blockchain-enabled networks are providing a real-time, shared, single version of the truth at the core of the business community. They eliminate data discrepancies, delays, and costs, while leveraging blockchain’s strong, decentralized, and trusted network. Best of all, it supports powerful new functionality such as chain of custody apps that run on the hybrid network. These shared apps empower shippers, carriers, freight forwarders, 3PLs/4PLs and other partners to track and manage orders and shipments, and collaboratively plan and execute across all stages of the supply chain, in a trusted, transparent, yet confidential environment. Considering the strategic role logistics play in business, how an organization approaches logistics can often dictate its overall success or failure. Blockchain enabled networks are creating an unprecedented advantage by greatly speeding how goods are moved throughout the supply chain by taking the guesswork out of process and ensuring all partners are operating on the same page.

MaryAnn Holder on One Network’s Intelligent Control Tower: One Network’s Intelligent Control Tower is not your typical control tower, that provides visibility to immediate trading partners only. The Intelligent Control Tower monitors, manages, and controls decisions and execution across functions and across companies to optimize the entire network. The Intelligent Control Tower uses AI and serves as a system of engagement across trading partners, and orchestrates companies, people and things to work together in real-time to serve the end consumer. Until recently, supply chain control towers have been all about providing visibility to your immediate trading partners. But with the development of multi-party, consumer-driven networks, advanced control towers now provide real-time visibility, collaboration and powerful AI capabilities to move beyond decision-support to decision-making and autonomous control.

“While many vendors just talk about bringing automation to their supply chain planning and inventory optimization software, One Network has customers that are live and using the capabilities to extract value from the technology,” said Seth Lippincott, lead analyst of the report. “By providing an integrated platform on which customers can run their supply chains end-to-end, the vendor is shortening the distance between planning and execution, providing a holistic view of inventory and the ability to optimize stocking levels. Nucleus expects the value One Network delivers to continue to improve as more customers adopt its automation and intelligent capabilities.” MaryAnn Holder-Browne, Chief Marketing Officer of One Network: “We are thrilled to once again be recognized by Nucleus Research”.

Coriolis flow meter supplier right now

Best thermal mass flow meter wholesale manufacturer? Beijing Sincerity is the leader of the coriolis mass flow meters industries in China,who specialized in producing thermal mass flow meter,turbine flow meter,fork density meters and ultrasonic flow meter. In line with our collaborative approach to our customers we are also able to discuss tailor-made Service and Support Solutions designed specifically for your needs that can include such topics as training, instrument replacement agreements and instant service and repair. Read additional info on thermal mass flow meter manufacturer.

China Capital technology group invested in the SINOPEC automation instrument department of Beijing institute of chemical industry. Beijing shouke shí huà automatic equipment Co., LTD (Beijing Sincerity’s predecessor) was officially established. “Shí huà” is the Chinese words from SINOPEC. Sincerity officially switched from a national company to joint-stock company. Beijing shouke shí Huá ( which is Beijing Sincerity Automatic Equipment Co., Ltd now ) was officially established. The Chinese pronunciation of “shí Huá “ and “ shí huà” are very close to each other. The 1st generation coriolis mass flow meters were officially launched. The coriolis mass flow meters are with all discrete components, little chips and LED digital display.

Second, the gas turbine flow meter equipment has strong functions, low power consumption and superior performance. When it is sold in the industry, it is found that the functional advantages of this kind of flowmeter will be more perfect. In many gas distribution stations or gas When promoting in the station, I found that the advantages will be more diversified, and there are more and more advantages. Third, the configuration of the natural gas turbine flow meter instrument is more perfect, and it will be more and more widely used. As long as you take a fancy to the above clarity, it will be more convenient in the process of normal use. After this is used in many gas distribution stations, it is found that the measurement accuracy is higher.

Thermal mass flow meters are suitable for all industrial and test platform applications that require fast, accurate gas measurement. The insertion thermal mass flow meter directly indicates the mass flow or standardized volume flow of the gas without any additional pressure and temperature compensation. They have impressive high accuracy, short response times and a very wide flow range, with almost no loss of accuracy even at the lowest flow. Discover additional info on bjssae.com.

What media can gas turbine flow meters measure? Is it good to use? Many industries rely heavily on the use of measuring tools, because many media must be measured before the capacity can be known, which has a great impact on production. It is precisely because of this that the use of measuring tools cannot be ignored. Nowadays, the use of gas turbine flow meters can bring about stable effects and has attracted the attention of many industries. So which media can be measured? Will it work well? Measurement of non-conductive liquids, if the electromagnetic flowmeter is dominant in the flow measurement of conductive liquids, in the field of non-conductive liquid flow measurement, the electromagnetic flowmeter is powerless, and the vortex This is where flow meters come in handy. Small diameter pipes introduced in recent years.